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Iversen, D. B., Dunvald, A. D., Jespersen, D. M., Nielsen, F., Brosen, K., Damkier, P., Potz, O.. . . Stage, T. B. (2023).  Flucloxacillin Is a Weak Inducer of CYP3A4 in Healthy Adults and 3D Spheroid of Primary Human Hepatocytes . Clin Pharmacol Ther

Jarvinen, E., Dalgard Dunvald, A. C., Ernst, M. T., Hammer, H. S., Potz, O., Pottegard, A., & Stage, T. B. (2023).  Dicloxacillin-Warfarin Drug-Drug Interaction – A Register-Based Study and In Vitro Investigations in 3D Spheroid Primary Human Hepatocytes . Br J Clin Pharmacol

Jarvinen, E., Hammer, H. S., Potz, O., Ingelman-Sundberg, M., & Stage, T. B. (2023).  3D Spheroid Primary Human Hepatocytes for Prediction of Cytochrome P450 and Drug Transporter Induction . Clin Pharmacol Ther

Vlasakova K, Steinhilber A, Bailey WJ, Erdos Z, Haag H, Joos T, Ackermann BL, Poetz O, Glaab WE. (2022). Plasma biomarkers tap, cpa1, and cpa2 for the detection of pancreatic injury in rat: The development of a novel multiplex ia-lc-ms/ms assay and biomarker performance evaluation. Arch Toxicol.

Wuerger LTD, Hammer HS, Hofmann U, Kudiabor F, Sieg H, Braeuning A. (2022). Okadaic acid influences xenobiotic metabolism in heparg cells. EXCLI J ;21:1053-65.

Knebel C, Sussmuth RD, Hammer HS, Braeuning A, Marx-Stoelting P. (2022). New approach methods for hazard identification: A case study with azole fungicides affecting molecular targets associated with the adverse outcome pathway for cholestasis. Cells ;11.

Kling S, Lang B, Hammer HS, Naboulsi W, Sprenger H, Frenzel F, Potz O, Schwarz M, Braeuning A, Templin MF. (2022). Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approaches. Biol Chem ;403:331-43.

Enge AM, Kaltner F, Gottschalk C, Kin A, Kirstgen M, Geyer J, These A, Hammer H, Potz O, Braeuning A, Hessel-Pras S. (2022). Organic cation transporter i and na(+) /taurocholate co-transporting polypeptide are involved in retrorsine- and senecionine-induced hepatotoxicity in heparg cells. Mol Nutr Food Res ;66:e2100800.

Pötz O, Joos TO, Stoll D, Templin MF. Massenspektrometriebasierte immunoassays. In: Kurreck J, Lottspeich F, Engels J, editors. Bioanalytik Heidelberg: Springer Nature; 2022. p. 415-22.

Kurreck J, Engels J, Lottspeich F. (2022). Bioanalytik. Heidelberg: Spektrum Akademischer Verlag.

Schmidt FF, Lichtenstein D, Planatscher H, Mentz A, Kalinowski J, Steinhilber AE, Joos TO, Braeuning A, Potz O. (2021). Pesticide mixture effects on liver protein abundance in heparg cells. Toxicology ;458:152839.

Michon A, Durrbach A, Gautier JC, Benain X, Lunven C, Jagerschmidt A, Aubert C, Poetz O, Joos T, Gury T, Becquemont L. (2021). Investigation of new biomarkers of kidney injury in renal transplant recipients undergoing graft biopsy. Clin Transplant ;35:e14408.

Lichtenstein D, Mentz A, Sprenger H, Schmidt FF, Albaum SP, Kalinowski J, Planatscher H, Joos TO, Poetz O, Braeuning A. (2021). A targeted transcriptomics approach for the determination of mixture effects of pesticides. Toxicology ;460:152892.

Lichtenstein D, Lasch A, Alarcan J, Mentz A, Kalinowski J, Schmidt FF, Potz O, Marx-Stoelting P, Braeuning A. An eight-compound mixture but not corresponding concentrations of individual chemicals induces triglyceride accumulation in human liver cells. Toxicology ;459:152857.

Lecrenier M-C, Marien A, Veys P, Belghit I, Dieu M, Gillard N, Henrottin J, Herfurth UM, Marchis D, Morello S, Oveland E, Poetz O, Rasinger JD, Steinhilber A, Baeten V, Berben G, Fumière O. (2021). Inter-laboratory study on the detection of bovine processed animal protein in feed by lc-ms/ms-based proteomics. Food Control ;125.

Kratzer U, Sommersdorf C, Maier S, Wagner TR, Templin M, Joos TO, Rothbauer U, Zeck A, Poetz O. (2021). Tris(hydroxymethyl)aminomethane compatibility with n-hydroxysuccinimide ester chemistry: Biotinylation of peptides and proteins in tris buffer. Bioconjug Chem;32:1960-5.

Ibrahim S, Lan C, Chabot C, Mitsa G, Buchanan M, Aguilar-Mahecha A, Elchebly M, Poetz O, Spatz A, Basik M, Batist G, Zahedi RP, Borchers CH. (2021). Precise quantitation of pten by immuno-mrm: A tool to resolve the breast cancer biomarker controversy. Anal Chem ;93:10816-24.

Hammer H, Schmidt F, Marx-Stoelting P, Potz O, Braeuning A. (2021) Cross-species analysis of hepatic cytochrome p450 and transport protein expression. Arch Toxicol ;95:117-33.

Froehlich BC, Popp R, Sobsey CA, Ibrahim S, LeBlanc A, Mohammed Y, Buchanan M, Aguilar-Mahecha A, Potz O, Chen MX, Spatz A, Basik M, Batist G, Zahedi RP, Borchers CH. (2021). A multiplexed, automated immuno-matrix assisted laser desorption/ionization mass spectrometry assay for simultaneous and precise quantitation of pten and p110alpha in cell lines and tumor tissues. Analyst ;146:6566-75.

Belghit I, Varunjikar M, Lecrenier M-C, Steinhilber A, Niedzwiecka A, Wang YV, Dieu M, Azzollini D, Lie K, Lock E-J, Berntssen MHG, Renard P, Fumière O, van Loonh OJJ, Larsene T, Poetz O, Braeuning A, Palmblad M, Rasinger JD. (2021). Future feed control – tracing banned bovine material in insect meal. Food Control ;128.

Anselm V, Steinhilber A, Sommersdorf C, Poetz O. (2021). Immunoaffinity-based liquid chromatography mass spectrometric assay to accurately quantify the protein concentration of hmgb1 in edta plasma. Methods Mol Biol ;2261:277-89.

Anselm V, Sommersdorf C, Carrasco-Triguero M, Katavolos P, Planatscher H, Steinhilber A, Joos T, Poetz O. (2020). Matrix and sampling effects on quantification of protein biomarkers of drug-induced liver injury. J Proteome Res ;20:4985-94.

Voss L, Yilmaz K, Burkard L, Vidmar J, Stock V, Hoffmann U, Potz O, Hammer HS, Peiser M, Braeuning A, Loschner K, Bohmert L, Sieg H. (2020) Impact of iron oxide nanoparticles on xenobiotic metabolism in heparg cells. Arch Toxicol ;94:4023-35.

Stage TB, Mortensen C, Khalaf S, Steffensen V, Hammer HS, Xiong C, Nielsen F, Poetz O, Svenningsen AF, Rodriguez-Antona C, Kroetz DL. (2020). P-glycoprotein inhibition exacerbates paclitaxel neurotoxicity in neurons and patients with cancer. Clin Pharmacol Ther.

Riffle B, Oesch F, Heckmanns A, Fabian E, Wang M, Samuga A, Ren P, Hammer H, Schmidt F, Potz O, van Ravenzwaay B, Landsiedel R. (2020). Xenobiotica-metabolizing enzyme induction potential of chemicals in animal studies: Nanostring ncounter gene expression and peptide group-specific immunoaffinity as accelerated and economical substitutions for enzyme activity determinations? Arch Toxicol.

Lichtenstein D, Mentz A, Schmidt FF, Luckert C, Buhrke T, Marx-Stoelting P, Kalinowski J, Albaum SP, Joos TO, Poetz O, Braeuning A. (2020). Transcript and protein marker patterns for the identification of steatotic compounds in human heparg cells. Food Chem Toxicol ;145:111690.

Ibrahim S, Froehlich BC, Aguilar-Mahecha A, Aloyz R, Poetz O, Basik M, Batist G, Zahedi RP, Borchers CH (2020). Using two peptide isotopologues as internal standards for the streamlined quantification of low-abundance proteins by immuno-mrm and immuno-maldi. Anal Chem ;92:12407-14.

Hammer H, Schmidt F, Heise T, Knebel C, Dabrowski A, Planatscher H, Kneuer C, Marx-Stoelting P, Potz O (2020). Induction and repression effects on cyp and transporter protein abundance by azole mixture uptake in rat liver. EXCLI J ;19:904-16.

Goedtke L, Sprenger H, Hofmann U, Schmidt FF, Hammer HS, Zanger UM, Poetz O, Seidel A, Braeuning A, Hessel-Pras S. (2020). Polycyclic aromatic hydrocarbons activate the aryl hydrocarbon receptor and the constitutive androstane receptor to regulate xenobiotic metabolism in human liver cells. Int J Mol Sci ;22.

Froehlich BC, Popp R, Sobsey CA, Ibrahim S, LeBlanc AM, Mohammed Y, Aguilar-Mahecha A, Poetz O, Chen MX, Spatz A, Basik M, Batist G, Zahedi RP, Borchers CH. (2020). Systematic optimization of the imaldi workflow for the robust and straightforward quantification of signalling proteins in cancer cells. Proteomics Clin Appl e2000034.

Braeuning A, Mentz A, Schmidt FF, Albaum SP, Planatscher H, Kalinowski J, Joos TO, Poetz O, Lichtenstein D. (2020). Rna-protein correlation of liver toxicity markers in heparg cells. EXCLI J 19:135-53.

Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz O. (2019). Application of mass spectrometry-based immunoassays for the species- and tissue-specific quantification of banned processed animal proteins in feeds. Anal Chem.

Niedzwiecka A, Boucharef L, Hahn S, Zarske M, Steinhilber AE, Poetz O, Zagon J, Seidler T, Braeuning A, Lampen A. (2019). A novel antibody-based enrichment and mass spectrometry approach for the detection of species-specific blood peptides in feed matrices. Food Control ;98:141-9.

Gross A, Kracher B, Kraus JM, Kuhlwein SD, Pfister AS, Wiese S, Luckert K, Potz O, Joos T, Van Daele D, De Raedt L, Kuhl M, Kestler HA. (2019). Representing dynamic biological networks with multi-scale probabilistic models. Commun Biol 2:21.

Dietrich J, Sommersdorf C, Gohlke S, Poetz O, Traenkle B, Rothbauer U, Hessel-Pras S, Lampen A, Braeuning A. (2019). Okadaic acid activates wnt/beta-catenin-signaling in human heparg cells. Arch Toxicol ;93:1927-39.

Zahn E, Wolfrum J, Knebel C, Heise T, Weiss F, Poetz O, Marx-Stoelting P, Rieke S. Mixture effects of two plant protection products in liver cell lines. Food Chem Toxicol 2018;112:299-309.

Weiss F, Hammer HS, Klein K, Planatscher H, Zanger UM, Noren A, Wegler C, Artursson P, Joos TO, Poetz O. (2018) Direct quantification of cytochromes p450 and drug transporters-a rapid, targeted mass spectrometry-based immunoassay panel for tissues and cell culture lysates. Drug Metab Dispos 46:387-96.

Steinhilber AE, Schmidt FF, Naboulsi W, Planatscher H, Niedzwiecka A, Zagon J, Braeuning A, Lampen A, Joos TO, Poetz O.  (2018) Species differentiation and quantification of processed animal proteins and blood products in fish feed using an 8-plex mass spectrometry-based immunoassay. J Agric Food Chem 66:10327-35.

Steinhilber, A. E., F. F. Schmidt, W. Naboulsi, H. Planatscher, A. Niedzwiecka, J. Zagon, A. Braeuning, A. Lampen, T. O. Joos and O. Poetz (2018). “Mass Spectrometry-Based Immunoassay for the Quantification of Banned Ruminant Processed Animal Proteins in Vegetal Feeds.Anal Chem.

Zahn, E., J. Wolfrum, C. Knebel, T. Heise, F. Weiss, O. Poetz, P. Marx-Stoelting and S. Rieke (2018). “Mixture effects of two plant protection products in liver cell lines.Food Chem Toxicol 112: 299-309.

Weiss, F., H. S. Hammer, K. Klein, H. Planatscher, U. M. Zanger, A. Noren, C. Wegler, P. Artursson, T. O. Joos and O. Poetz (2018). “Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates.Drug Metab Dispos 46(4): 387-396.

MacLean, C., F. Weiss, O. Poetz and T. Ebner (2017). “Concept: The Use of Targeted Immunoaffinity Proteomics for Routine Assessment of In Vitro Enzyme Induction.J Pharm Sci 106(12): 3453-3457.

Marx-Stoelting, P., K. Ganzenberg, C. Knebel, F. Schmidt, S. Rieke, H. Hammer, F. Schmidt, O. Potz, M. Schwarz and A. Braeuning (2017). “Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.Arch Toxicol 91(8): 2895-2907.

Popp, R., H. Li, A. LeBlanc, Y. Mohammed, A. Aguilar-Mahecha, A. G. Chambers, C. Lan, O. Poetz, M. Basik, G. Batist and C. H. Borchers (2017). “Immuno-Matrix-Assisted Laser Desorption/Ionization Assays for Quantifying AKT1 and AKT2 in Breast and Colorectal Cancer Cell Lines and Tumors.Anal Chem 89(19): 10592-10600.

Wegler, C., F. Z. Gaugaz, T. B. Andersson, J. R. Wisniewski, D. Busch, C. Groer, S. Oswald, A. Noren, F. Weiss, H. S. Hammer, T. O. Joos, O. Poetz, B. Achour, A. Rostami-Hodjegan, E. van de Steeg, H. M. Wortelboer and P. Artursson (2017). “Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.Mol Pharm 14(9): 3142-3151.

Gautier, J. C., X. Zhou, Y. Yang, T. Gury, Z. Qu, X. Palazzi, J. F. Leonard, M. Slaoui, Y. Veeranagouda, I. Guizon, E. Boitier, A. Filali-Ansary, B. H. J. van den Berg, O. Poetz, T. Joos, T. Zhang, J. Wang, P. Detilleux and B. Li (2016). “Evaluation of novel biomarkers of nephrotoxicity in Cynomolgus monkeys treated with gentamicin.Toxicol Appl Pharmacol 303: 1-10.

Groll, N., T. Petrikat, S. Vetter, S. Colnot, F. Weiss, O. Poetz, T. O. Joos, U. Rothbauer, M. Schwarz and A. Braeuning (2016). “Coordinate regulation of Cyp2e1 by beta-catenin- and hepatocyte nuclear factor 1alpha-dependent signaling.Toxicology 350-352: 40-48.

Groll, N., T. Petrikat, S. Vetter, C. Wenz, J. Dengjel, C. Gretzmeier, F. Weiss, O. Poetz, T. O. Joos, M. Schwarz and A. Braeuning (2016). “Inhibition of beta-catenin signaling by phenobarbital in hepatoma cells in vitro.Toxicology 370: 94-105.

Schmidt, F., P. Marx-Stoelting, W. Haider, T. Heise, C. Kneuer, M. Ladwig, S. Banneke, S. Rieke and L. Niemann (2016). “Combination effects of azole fungicides in male rats in a broad dose range.Toxicology 355-356: 54-63.

Weiss, F., A. Schnabel, H. Planatscher, B. H. van den Berg, B. Serschnitzki, A. K. Nuessler, W. E. Thasler, T. S. Weiss, M. Reuss, D. Stoll, M. F. Templin, T. O. Joos, K. Marcus and O. Poetz (2015). “Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry.Sci Rep 5: 8759.

Planatscher, H., F. Weiss, D. Eisen, B. H. van den Berg, A. Zell, T. Joos and O. Poetz (2014). “Identification of short terminal motifs enriched by antibodies using peptide mass fingerprinting.Bioinformatics 30(9): 1205-1213.

Weiss, F., B. H. van den Berg, H. Planatscher, C. J. Pynn, T. O. Joos and O. Poetz (2014). “Catch and measure-mass spectrometry-based immunoassays in biomarker research.Biochim Biophys Acta 1844(5): 927-932.

Eisen, D., H. Planatscher, D. B. Hardie, U. Kraushaar, C. J. Pynn, D. Stoll, C. Borchers, T. O. Joos and O. Poetz (2013). “G protein-coupled receptor quantification using peptide group-specific enrichment combined with internal peptide standard reporter calibration.J Proteomics 90: 85-95.

Volk, S., T. D. Schreiber, D. Eisen, C. Wiese, H. Planatscher, C. J. Pynn, D. Stoll, M. F. Templin, T. O. Joos and O. Potz (2012). “Combining ultracentrifugation and peptide termini group-specific immunoprecipitation for multiplex plasma protein analysis.Mol Cell Proteomics 11(7): O111 015438.

Bauer, M., A. Chicca, M. Tamborrini, D. Eisen, R. Lerner, B. Lutz, O. Poetz, G. Pluschke and J. Gertsch (2012). “Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.J Biol Chem 287(44): 36944-36967.

Hoeppe, S., T. D. Schreiber, H. Planatscher, A. Zell, M. F. Templin, D. Stoll, T. O. Joos and O. Poetz (2011). “Targeting peptide termini, a novel immunoaffinity approach to reduce complexity in mass spectrometric protein identification.Mol Cell Proteomics 10(2): M110 002857.

Planatscher, H., J. Supper, O. Poetz, D. Stoll, T. Joos, M. F. Templin and A. Zell (2010). “Optimal selection of epitopes for TXP-immunoaffinity mass spectrometry.Algorithms Mol Biol 5: 28.

Poetz, O., S. Hoeppe, M. F. Templin, D. Stoll and T. O. Joos (2009). “Proteome wide screening using peptide affinity capture.Proteomics 9(6): 1518-1523.

Posters

SOT 2024 Salt Lake City

Poster 349: Development of protein-based assay methods for authentication of insects in food and feed


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Poster 392: Assay validation and quantification of novel protein safety biomarker candidates for the detection of glomerular injury in clinical specimens

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Poster 413: Development and validation of assay methods for novel mechanistic protein biomarkers of drug-induced liver injury (DILI)

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Poster 432: In vitro models to determine the pre-systemic metabolism of the human intestine following oral administration


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Poster 725: Assessing Hepatotoxic and Nephrotoxic Compounds in HepaRG and RPTEC Cells by Key Signaling Events Using Multiplexed Microsphere-Based Sandwich Immunoassays

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ISSX 2023

In vitro models to determine human intestinal presystemic metabolism after oral dosing